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913286

Sigma-Aldrich

Methoxypolyethylene epoxide

PEG average Mn 750

Synonym(s):

Epoxide PEG, mPEG-epoxide

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About This Item

Linear Formula:
C3H5O2(C2H4O)nCH3
UNSPSC Code:
43211915
NACRES:
NA.23

form

semisolid

mol wt

PEG average Mn 750
average Mn 750 (by NMR)

color

white to off-white

Ω-end

(epoxide)

α-end

methoxy

polymer architecture

shape: linear
functionality: monofunctional

storage temp.

2-8°C

Application

Epoxide functionalized PEG can be covalently bonded to polymers and biopolymers by epoxide ring-opening reactions. As a surface coating, PEGylated surfaces prevent cell adhesion by entropically driven steric repulsion. For drug delivery, PEGylation increases the hydrophilicity of the drug carrier.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Rajesh Kumar Kainthan et al.
Biomaterials, 27(31), 5377-5390 (2006-07-21)
A novel class of hyperbranched polymers based on polyglycerol (PG) and poly(ethylene glycol) (PEG) are synthesized by multibranching anionic ring opening polymerization. Multivalent cationic sites are added to these polymers by a post-amination and quarternization reactions. Blood compatibility studies using
Mohamed H Ramadan et al.
Langmuir : the ACS journal of surfaces and colloids, 30(25), 7485-7495 (2014-06-04)
We report a thermoresponsive chemical modification strategy of hyaluronic acid (HA) for coating onto a broad range of biomaterials without relying on chemical functionalization of the surface. Poly(di(ethylene glycol) methyl ether methacrylate) (PMEO2MA), a polymer with a lower critical solution
Rajesh Kumar Kainthan et al.
Biomacromolecules, 9(3), 886-895 (2008-02-06)
This paper discusses the binding and release properties of hydrophobically modified hyperbranched polyglycerol-polyethylene glycol copolymers that were originally developed as human serum albumin (HSA) substitutes. Their unimolecular micellar nature in aqueous solution has been proven by size measurements and other
Jameel Ahmad Khan et al.
Biomacromolecules, 7(5), 1386-1388 (2006-05-09)
Recent advances in understanding biological systems have proven that RNA is not merely the carrier of genetic information, but also a key molecule in regulation of gene expression and other crucial metabolic processes. Therefore, it is being considered as an
Rajesh K Kainthan et al.
Biomaterials, 29(11), 1693-1704 (2008-01-16)
There is a huge clinical demand for Human Serum Albumin (HSA), with a world market of approximately $1.5B/year. Concern over prion and viral transmission in the blood supply has led to a need for safer substitutes and offers the opportunity

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