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Sigma-Aldrich

(R)-(−)-2-Amino-1-propanol

98%

Synonym(s):

D-Alaninol

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About This Item

Linear Formula:
CH3CH(NH2)CH2OH
CAS Number:
35320-23-1
Molecular Weight:
75.11
Beilstein:
1718866
MDL number:
MFCD00064413
UNSPSC Code:
12352116
PubChem Substance ID:
24857919
NACRES:
NA.22

Assay

98%

optical activity

[α]19/D −18°, neat

optical purity

ee: 97% (GLC)

refractive index

n20/D 1.4493 (lit.)

bp

166-168 °C (lit.)

density

0.963 g/mL at 20 °C (lit.)

SMILES string

C[C@@H](N)CO

InChI

1S/C3H9NO/c1-3(4)2-5/h3,5H,2,4H2,1H3/t3-/m1/s1

InChI key

BKMMTJMQCTUHRP-GSVOUGTGSA-N

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General description

(R)-(-)-2-Amino-1-propanol is a chiral secondary amine.

Application

(R)-(-)-2-Amino-1-propanol has been used as a derivatizing agent for gossypol during the analysis of gossypol enantiomers in cottonseed by high-performance liquid chromatography.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

181.4 °F - closed cup

Flash Point(C)

83 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of (+)-,(-)-, and total gossypol in cottonseed by high-performance liquid chromatography.
Hron RJ, et al.
Journal of the American Oil Chemists' Society, 76(11), 1351-1355 (1999)
A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer.
Schelman WR, et al.
Investigational New Drugs, 32(2), 295-302 (2014)
A synthetic molecular pentafoil knot.
Ayme J-F, et al.
Nature Chemistry, 4(1), 15-20 (2012)
William R Schelman et al.
Investigational new drugs, 32(2), 295-302 (2013-07-19)
A phase I, dose-escalation study of AT-101 with cisplatin and etoposide was conducted to determine the maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), safety and pharmacokinetics in patients with advanced solid tumors, with an expanded cohort in patients with
Neslihan Beyazit et al.
Carbohydrate polymers, 240, 116333-116333 (2020-06-02)
In this work, two new chitosan-Schiff base derivatives (HCS-GSP and LCS-GSP) were synthesized by the condensation reaction of high molecular weight chitosan (HCS) and low molecular weight chitosan (LCS) with (-)-gossypol (GSP), respectively. For this purpose, racemic gossypol was isolated

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