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SML3634

Sigma-Aldrich

TRULI

≥98% (HPLC)

Synonym(s):

N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

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5 MG
€105.00
25 MG
€424.00

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5 MG
€105.00
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About This Item

Empirical Formula (Hill Notation):
C18H14N4OS
CAS Number:
1424635-83-5
Molecular Weight:
334.39
UNSPSC Code:
12352200
NACRES:
NA.77

€105.00

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CNC2=C1C=CC=N2)N=C3SC=CN3CC4=CC=CC=C4

InChI

1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)

InChI key

VTXBMVZVPUSAJF-UHFFFAOYSA-N

Biochem/physiol Actions

Cell penetrant, potent and non-toxic activator of Yap signaling; inhibitor of Lats kinases
TRULI is a call penetrant, potent and non-toxic activator of Yap signaling. TRULI is an ATP-competitive inhibitor of Lats kinases (the core enzymes in Hippo signaling) that induces robust Yap nuclear translocation and prevents Yap phosphorylation. TRULI induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000410139
0000410135
0000410139
0000410135
0000339022

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Nathaniel Kastan et al.
Nature communications, 12(1), 3100-3100 (2021-05-27)
Hippo signaling is an evolutionarily conserved pathway that restricts growth and regeneration predominantly by suppressing the activity of the transcriptional coactivator Yap. Using a high-throughput phenotypic screen, we identified a potent and non-toxic activator of Yap. In vitro kinase assays

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