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SML2399

Sigma-Aldrich

ML327

≥98% (HPLC)

Synonym(s):

1,2-Dihydro-2-oxo-N-[3-[[(5-phenyl-3-isoxazolyl)carbonyl]amino]propyl]-3-pyridinecarboxamide, CID 60167648

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5 MG
€113.00
25 MG
€360.00

€113.00

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5 MG
€113.00
25 MG
€360.00

About This Item

Empirical Formula (Hill Notation):
C19H18N4O4
CAS Number:
1883510-31-3
Molecular Weight:
366.37
MDL number:
MFCD31619239
UNSPSC Code:
12352200
NACRES:
NA.77

€113.00

Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[nH]1[c](c(ccc1)C(=O)NCCCNC(=O)c2n[o]c(c2)c3ccccc3)=O

InChI key

NNNDNXLMQAPQQQ-UHFFFAOYSA-N

Biochem/physiol Actions

ML327 is a regulator of E-cadherin transcription that restores E-cadherin expression in cancer cell lines and partially reverses Epithelial-to-Mesenchymal Transition (EMT). It is a potent inducer of mesenchymal-to-epithelial transition (MET) in epithelial cancers. Apparently ML327 blocks MYC expression in neuroblastomas. It induces apoptosis in cancer cells and sensitizes Ewing sarcoma cells to TRAIL.
regulator of E-cadherin transcription that restores E-cadherin expression in cancer cell lines; inducer of mesenchymal-to-epithelial transition (MET)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Hanbing An et al.
Oncotarget, 6(26), 22934-22948 (2015-06-18)
Transcriptional repression of E-cadherin is a hallmark of Epithelial-to-Mesenchymal Transition (EMT) and is associated with cancer cell invasion and metastasis. Understanding the mechanisms underlying E-cadherin repression during EMT may provide insights into the development of novel targeted therapeutics for cancer.
Eric J Rellinger et al.
Biochemical and biophysical research communications, 491(2), 463-468 (2017-07-19)
Ewing sarcomas are rare mesenchymal-derived bone and soft tissue tumors in children. Afflicted children with distant metastases have poor survival despite aggressive therapeutics. Epithelial-to-mesenchymal transition in epithelial carcinomas is associated with loss of E-cadherin and resistance to apoptosis. ML327 is
Chandrasekhar Padmanabhan et al.
Oncotarget, 8(60), 101072-101086 (2017-12-20)
Epithelial cancers (carcinomas) comprise the top four causes of cancer-related deaths in the United States. While overall survival has been steadily improving, therapy-resistant disease continues to present a major therapeutic challenge. Carcinomas often exploit the normal developmental program, epithelial-to-mesenchymal transition

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