SML0826

FH1

≥98% (HPLC)

• Synonym(s): BRD-K4477, N,N′-(Methylenedi-4,1-phenylene)bis-acetamide, N,N′-(Methylenedi-4,1-phenylene)diacetamide, NSC 12407
• Empirical Formula (Hill Notation): C₁₇H₁₈N₂O₂
• CAS Number: 2719-05-3
• Molecular Weight: 282.34
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: N(c1ccc(cc1)Cc2ccc(cc2)NC(=O)C)C(=O)C
• InChI: 1S/C17H18N2O2/c1-12(20)18-16-7-3-14(4-8-16)11-15-5-9-17(10-6-15)19-13(2)21/h3-10H,11H2,1-2H3,(H,18,20)(H,19,21)
• InChI key: OEXMNSOPAKOPEF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

FH1 (BRD-K4477) was found to enhance hepatocyte functions and promote the differentiation of induced pluripotent stem cell–derived hepatocytes toward a more mature phenotype than what had previouslybeen obtainable. Human induced pluripotent stem (iPS) cells that are differentiated toward hepatocyte-like (iHep) cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. Cultures treated with both FH1 (BRD-K4477) and another compound that induces proliferation, FPH1 (BRD-6125), contained larger colonies of iHep cells, which showed more pronounced hepatocyte morphologies with a more mature phenotype than previously obtainable.

FH1 (BRD-K4477) was found to enhance hepatocyte functions and promote the differentiation of induced pluripotent stem cell–derived hepatocytes toward a more mature phenotype.

Safety Information

• Pictograms: GHS09
• Signal Word: Warning
• Hazard Statements: H400
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable