Purchased this product through Sigma. There was a delay between time of purchase and time of delivery. Product arrived and tested in western blotting at dilution 1:1000 and showed multiple non specific bands on gel making data uninterpretable. Western blotting conditions: Blocking 1hr in 5% Milk TBST, Probed o/night 1:1000 in blocking buffer, after three washes secondary antibody Rabbit HRP at 1:10000 (PTG) and developed with ECL Fempto (UltraScence Femto Western Substrate)
SAB5700618
Anti-Lamin A/C antibody produced in rabbit
Anti-Lamin A/C antibody produced in rabbit
Synonym(s):
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNA, LMNC, LMNL1
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100 μL
€316.00
€316.00
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100 μL
€316.00
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
€316.00
Please contact Customer Service for Availability
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biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
62-74
species reactivity
human, mouse, rat
concentration
1.41 mg/ml
technique(s)
immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
immunoprecipitation (IP): 1:50-1:200
western blot: 1:500-1:2000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LMNA(4000)
General description
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 403-572 of human Lamin C (NP_005563.1).
Physical form
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Storage and Stability
Store at -20℃. Avoid freeze / thaw cycles.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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