The voltage-dependent potassium channel (Kv1.3/KCNA3) is expressed in the nervous and immune systems. This gene is located on human chromosome 1p13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Kv1.3/KCNA3 around the phosphorylation site of Tyr135.
Immunogen Range: 101-150
Biochem/physiol Actions
The voltage-dependent potassium channel (Kv1.3/KCNA3) plays a major role in setting the resting membrane potential, cell proliferation, apoptosis and volume regulation. This protein participates in immunomodulation of autoreactive effector and memory T cell-mediated autoimmune diseases. KCNA3 is required for T-cell proliferation and activation.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The Journal of clinical investigation, 130(8), 4195-4212 (2020-07-01)
Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of these targets can provide potential treatments to halt disease progression. Here, we demonstrated that microglial Kv1.3, a voltage-gated
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