The CLDN4 (claudin 4) gene is mapped to human chromosome 7q11.23. The encoded protein is an integral member, localized to tight junction. It is also expressed in the epithelial basolateral membrane.
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 4.
Immunogen Range: 160-209
Biochem/physiol Actions
CLDN4 (claudin 4) is associated with epithelial differentiation, and is widely implicated in carcinomas. Its expression is considered to differentiate carcinoma with that of sarcoma. Claudin 4 expression is implicated in gastric cancer induced by Helicobacter pylori infection. It contributes to invasion, metastasis and prognosis of the disease. The CLDN4 gene is known to be overexpressed in a number of chemoresistant and metastatic cancer. Its localization to the tight junction prevents paracellular diffusion. Along with this, the extracellular loop interaction mediated by claudin 4 with the neighbouring cells makes it a differentiation marker.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Claudin-4 activity in ovarian tumor cell apoptosis resistance and migration
Hicks DA, et al.
BMC Cancer, 16(1), 788-788 (2016)
Claudin-4 expression distinguishes SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas
Schaefer IM, et al.
Modern Pathology, 30(4), 539-539 (2017)
Claudin-1,-3 and-4 proteins and mRNA expression in benign and malignant breast lesions: a research study
Thokes AM, et al.
Breast Cancer Research, 7(2), R296-R296 (2005)
Role of TGF-beta-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer
Rachakonda G, et al.
Cellular Signalling, 28(10), 1537-1544 (2016)
TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells
Chavarria-Velazquez CO, et al.
Immunobiology, 223(1), 38-48 (2018)
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