Anti-CNPase antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the 11-5B hybridoma produced by the fusion of mouse myeloma cells and splenocytes from RBF/Dn mouse immunized with human 2α,3α-cyclic nucleotide 3α-phosphodiesterase. CNPase (2α,3α-cyclic nucleotide 3α-phosphodiesterase), also known as CNP, is a membrane-anchored enzyme within the myelin sheath. CNPase is primarily a heterodimer of approximately 94 kDa. The heterodimer consists of a varied proportion of CNPase isoforms CNP1 (46 kDa) and CNP2 (48 kDa).
Immunogen
Human 2′,3′-cyclic nucleotide 3′-phosphodiesterase
Application
Anti-CNPase antibody, Mouse monoclonal has been used in immunoblotting, immunohistochemistry.
Biochem/physiol Actions
CNPase (2α,3α-cyclic nucleotide 3α-phosphodiesterase), interacts with cytoskeletal proteins, cholesterol-rich cell membranes, nucleotides and various other proteins. Abnormalities in CNPase expression cause perturbations in myelin structure and are associated with neurological diseases such as schizophrenia and multiple sclerosis. It was shown that CNPase can bind Gag structural protein and prevent the assembly of HIV-1 particle, demonstrating the anti-viral activity of CNPase.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
2?, 3?-cyclic nucleotide phosphodiesterase (CNPase) as a target in neurodegenerative diseases
Baburina Y L, et al.
Neurochemical Journal, 7(1), 1-15 (2013)
2', 3'-cyclic nucleotide 3'-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system.
Sprinkle T J.
Critical Reviews in Neurobiology, 4(3), 235-301 (1989)
Inhibition of HIV-1 particle assembly by 2?, 3?-cyclic-nucleotide 3?-phosphodiesterase
Wilson S J, et al.
Cell host & microbe, 12(4), 585-597 (2012)
Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium.
Paes-Colli, et al.
Frontiers in Cellular Neuroscience, 17, 1134130-1134130 (2023)
Frontiers in aging neuroscience, 12, 590530-590530 (2020-11-17)
Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term
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