SAB3500010

Anti-FNIP2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution, ab2

• Synonym(s): Anti-FNIPL, Anti-Folliculin interacting protein 2
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, mouse, human
• technique(s): indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: NP_065891
• UniProt accession no.: Q9P278
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FNIP2(57600)

Description

General description

Folliculin interacting protein 2 (FNIP2) is a 125.6kDa protein expressed in the cytoplasm.

Immunogen

FNIP2 antibody was raised against an 18 amino acid peptide near the amino terminus of human FNIP2.

Biochem/physiol Actions

Folliculin interacting protein 2 (FNIP2) induces apoptosis. It associates with AMP-activated protein kinase (AMPK) and folliculin (FLCN). The protein also has a role in the O⁶-methylguanine-induced apoptosis signaling pathway.

Features and Benefits

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Target description

FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500010.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable