This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)
Immunogen
GLI1 (AAH13000.1, 401 a.a. ~ 500 a.a) partial recombinant protein with GST-pstS1 tag.
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Physical form
Solution in phosphate buffered saline, pH 7.4
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