Store stock solutions of item S1198, Sumatriptan succinate for several months at -20°C.
S1198
Sumatriptan succinate
≥98% (HPLC), solid, 5-HT₁ receptor agonist
Synonym(s):
3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate, GR-43175
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10 MG
€131.00
50 MG
€514.00
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10 MG
€131.00
50 MG
€514.00
About This Item
Empirical Formula (Hill Notation):
C14H21N3O2S · C4H6O4
CAS Number:
Molecular Weight:
413.49
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Sumatriptan succinate, ≥98% (HPLC), solid
Quality Level
Assay
≥98% (HPLC)
form
solid
color
white to beige
solubility
H2O: >20 mg/mL
originator
GlaxoSmithKline
SMILES string
OC(=O)CCC(O)=O.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
InChI
1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
InChI key
PORMUFZNYQJOEI-UHFFFAOYSA-N
Gene Information
human ... HTR1B(3351) , HTR1D(3352)
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Biochem/physiol Actions
Sumatriptan succinate has the ability to constrict human cranial arteries.[1] This 5-HT1 receptor agonist can be used to treat migraine.[2]
Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 3 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Treatment of acute migraine with subcutaneous sumatriptan
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Mucoadhesive bilayered patches for administration of sumatriptan succinate
Shidhaye SS, et al.
Aaps Pharmscitech, 9(3), 909-916 (2008)
Tse-Ming Chou et al.
The journal of headache and pain, 23(1), 157-157 (2022-12-13)
To investigate specific brain regions and neural circuits that are responsible for migraine chronification. We established a mouse model of chronic migraine with intermittent injections of clinically-relevant dose of nitroglycerin (0.1 mg/kg for 9 days) and validated the model with cephalic and
Shree G Sharma et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 61(2), 326-329 (2012-12-05)
Renal cortical infarction is a rare cause of acute kidney injury that results from inadequate blood flow to the kidney, most commonly as a consequence of thrombotic or embolic occlusion of the renal artery or profound hypoperfusion. We report the
Nahid Shahabadi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 99, 18-22 (2012-10-09)
The interaction of native calf thymus DNA with sumatriptan(1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide) at physiological pH was studied by spectrophotometry, circular dichroism, voltammetry and viscosimetric techniques. Sumatriptan molecule intercalated between base pairs of DNA, showed by a sharp increase in specific viscosity of DNA.
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