The lab has not validated the product for use in animal studies. For the injection of 5-Pregnen-3β-ol-20-one-16α-carbonitrile using a vehicle solution, a publication suggests that 5% dimethyl sulfoxide in safflower oil may be effective. This finding was published in the Journal of Nuclear Medicine, July 2020 issue, Volume 61, Issue 7, on pages 1050-1057. The publication, titled "Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a β-Amyloidosis Mouse Model with 11C-Metoclopramide PET," is indexed with PMID: 31806767.
P0543
5-Pregnen-3β-ol-20-one-16α-carbonitrile
≥97%
Synonym(s):
Pregnenolone-16α-carbonitrile
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All Photos(4)
About This Item
Empirical Formula (Hill Notation):
C22H31NO2
CAS Number:
Molecular Weight:
341.49
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
biological source
synthetic (organic)
Quality Level
sterility
non-sterile
Assay
≥97%
form
powder, crystals or chunks
technique(s)
cell culture | mammalian: suitable
solubility
chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat)
shipped in
ambient
storage temp.
2-8°C
SMILES string
C[C@@]12[C@](C[C@@H](C#N)[C@@H]2C(C)=O)([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1
InChI
1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
InChI key
VSBHRRMYCDQLJF-ZDNYCOCVSA-N
Related Categories
Application
Biochem/physiol Actions
Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.[3]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
>199.9 °F - closed cup
Flash Point(C)
> 93.3 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Yongjie Ma et al.
PloS one, 7(6), e38734-e38734 (2012-06-23)
Pregnane X receptor (PXR) is known to function as a xenobiotic sensor to regulate xenobiotic metabolism through selective transcription of genes responsible for maintaining physiological homeostasis. Here we report that the activation of PXR by pregnenolone 16α-carbonitrile (PCN) in AKR/J
Gene expression profiling of drug metabolism and toxicology markers using a low-density DNA microarray
de Longueville F, et al.
Biochemical Pharmacology, 64(1), 137-149 (2002)
Afonso C D Bainy et al.
Aquatic toxicology (Amsterdam, Netherlands), 142-143, 447-457 (2013-10-15)
The pregnane X receptor (PXR) (nuclear receptor NR1I2) is a ligand activated transcription factor, mediating responses to diverse xenobiotic and endogenous chemicals. The properties of PXR in fish are not fully understood. Here we report on cloning and characterization of
Guncha Taneja et al.
Scientific reports, 9(1), 6663-6663 (2019-05-02)
Cytochrome P450 (CYP)3A is the most abundant CYP enzyme in the human liver, and a functional impairment of this enzyme leads to unanticipated adverse reactions and therapeutic failures; these reactions result in the early termination of drug development or the
Nozomu Moriya et al.
Biological & pharmaceutical bulletin, 35(4), 473-480 (2012-04-03)
Infection-associated inflammation can alter the expression levels and functions of cytochrome P450s (CYPs). Cyp gene expression is regulated by the activation of several nuclear receptors, including pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR). These
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What delivery solvent is recommended for IP injection of 5-Pregnen-3β-ol-20-one-16α-carbonitrile into mice?
1 answer-
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