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L2270

Sigma-Aldrich

Lys-Ala 4-methoxy-β-naphthylamide dihydrochloride

dipeptidylpeptidase II substrate

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250 MG
€605.00

€605.00

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250 MG
€605.00

About This Item

Empirical Formula (Hill Notation):
C20H28N4O3 · 2HCl
CAS Number:
118357-26-9
Molecular Weight:
445.38
MDL number:
MFCD00155571
UNSPSC Code:
12352204
PubChem Substance ID:
24896308
NACRES:
NA.28

€605.00

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Quality Level

200

Assay

≥97.5% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to yellow (and colorless to faint brown and colorless to brown-yellow)

storage temp.

−20°C

SMILES string

Cl.Cl.COc1cc(NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN)cc2ccccc12

InChI

1S/C20H28N4O3.2ClH/c1-13(23-20(26)17(22)9-5-6-10-21)19(25)24-15-11-14-7-3-4-8-16(14)18(12-15)27-2;;/h3-4,7-8,11-13,17H,5-6,9-10,21-22H2,1-2H3,(H,23,26)(H,24,25);2*1H/t13-,17-;;/m0../s1

InChI key

GJOOJLYXFGXARX-ZMQOMOPGSA-N

Application

Lys-Ala 4-methoxy-β-naphthylamide dihydrochloride has been used as a substrate to measure the dipeptidyl peptidase II (DPPII) from Vigna radiata seeds.

Substrates

Fluorogenic substrate for dipeptidyl aminopeptidase II.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL7714
BCCM2548
BCCG5368
BCCF0189
BCBX4977

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R Gossrau et al.
Histochemistry, 70(1), 53-76 (1980-01-01)
The activity of dipeptidylpeptidase II (DPP II; E.C. 3.4.14.2) was investigated by biochemical and histochemical methods in rat, mouse and guinea-pig organs as well as in human enterobiopsies. Lys-Pro-MNA and Ala-Pro-MNA showed the most favorable kinetic properties (Km, Vmax) and
F A Dolbeare et al.
Clinical chemistry, 23(8), 1485-1491 (1977-08-01)
Enzyme activity can be measured in single cells or in cell suspensions by either static or flow microfluorometry when a fluorogenic substrate is used. We have used amino acid derivatives of arylamines as fluorogenic substrates for tagging cellular proteinases. The

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