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I1774

Sigma-Aldrich

Iturin A from Bacillus subtilis

≥95% (HPLC), suitable for microbiological culture

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1 MG
€185.00
5 MG
€684.00

About This Item

CAS Number:
52229-90-0
MDL number:
MFCD01094135
UNSPSC Code:
12352202
NACRES:
NA.61

€185.00

Please contact Customer Service for Availability
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Product Name

Iturin A from Bacillus subtilis, ≥95% (HPLC)

biological source

Bacillus subtilis

Quality Level

200

Assay

≥95% (HPLC)

form

powder

technique(s)

microbiological culture: suitable

color

white to yellow

solubility

ethanol: soluble 9.80-10.20 mg/mL

antibiotic activity spectrum

fungi

Mode of action

cell membrane | interferes

storage temp.

2-8°C

Application

Iturin A was used in the study of Bacillomycin D (an iturin with antifungal activity against Aspergillus flavus).[1]

Biochem/physiol Actions

IturinA exhibits strong antifungal activity against pathogenic yeast and fungi.[2] It interacts with the cytoplasmic membrane of the target cell forming ion conducting pores[3]. Its mode of action could be attributed to its interaction with sterols and phospholipids. The compound causes the release of exo-vesicles from human erythrocytes.[4]

Other Notes

A family of lipopeptides characterized by a heptapeptide cyclized with a C13-C17 β-amino fatty acid. Composed mainly of C14-C15 β-amino acids.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000410402
0000383063
0000383064
0000377029
0000410402

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Minakshi Grover et al.
Current microbiology, 60(2), 99-106 (2009-09-25)
Bacillus subtilis strain RP24, isolated from rhizoplane of field grown pigeon pea, exhibited in vitro antagonism against a wide range of phytopathogenic fungi. An attempt was made to partially purify and characterize the diffusible antifungal metabolite/s produced by the strain
R V Velho et al.
Letters in applied microbiology, 52(6), 660-666 (2011-04-20)
To investigate the expression of sboA and ituD genes among strains of Bacillus spp. at different pH and temperature. Different Bacillus strains from the Amazon basin and Bacillus subtilis ATCC 19659 were investigated for the production of subtilosin A and
S Mizumoto et al.
Applied microbiology and biotechnology, 75(6), 1267-1274 (2007-04-25)
Enhanced production of the antibiotic iturin A by Bacillus subtilis RB14-CS reached 4.4 g L(-1) in SM medium containing soybean meal and maltose, which was 16-fold and 2.2-fold higher than that in original and modified number 3S media, respectively. When
Katarzyna Czaczyk et al.
Polish journal of microbiology, 57(4), 313-319 (2008-01-01)
Cell surface hydrophobicity (CSH) is recognised as a important factor in microbial adhesion to solid surfaces. Growth conditions have been found to determine the synthesis of extracellular molecules by microorganisms. It has major consequences in modification of bacterial surface properties
E Jourdan et al.
Molecular plant-microbe interactions : MPMI, 22(4), 456-468 (2009-03-11)
Multiple strains of Bacillus subtilis were demonstrated to stimulate plant defense responses, and cyclic lipopeptides may be involved in the elicitation of this induced systemic resistance phenomenon. Here, we further investigated molecular events underlying the interaction between such lipopeptides and
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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