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GERPN6301

Thiourea

Cytiva RPN6301, pack of 100 g

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About This Item

UNSPSC Code:
41105323
NACRES:
NA.77

form

solid

feature

wetted part: no

packaging

pack of 100 g

manufacturer/tradename

Cytiva RPN6301

color

White

pH range

5-7

solubility

cold water: soluble (Soluble in cold water and hot water)
diethyl ether: soluble (Partially soluble in diethyl ether)
methanol: soluble (Easily soluble in methanol)

General description

Thiourea is a chaotrope used together with urea in the IPG strip rehydration to solubilize and denature proteins, and improve the solubility of membrane proteins.

Application

Thiourea has been used as a component of lysis buffer for solubilization of the proteins from tissue samples and T-leukemia cells. It has also been used as a component of sample buffer for placental tissue, leaf proteome, and 2D electrophoresis.

Biochem/physiol Actions

Thiourea is an organic compound and its derivatives have antibacterial, antiviral, antifungal and insecticidal property. It is actively used in the drug development against human immunodeficiency virus (HIV) and hepatitis C infection. Thiourea inhibits cyclooxygenase enzyme and effectively reduces prostaglandin E2 (PGE2) and thromboxane (TXB2) production and is antithrombotic in human platelets. It is cytotoxic to vaginal epithelial cells and may function as potent spermicidal agent. Thiourea based derivatives of anticancer drug sorafenib, eliclits antiproliferative activity in human colon cancer cell line, HCT116 cells.

Storage and Stability

Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.

Analysis Note

To view the Certificate of Analysis for this product, please visit www.cytiva.com.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H302,H361d,H351,H411

Storage Class Code

13 - Non Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Spontaneous Unexplained Preterm Labor with Intact Membrane: Finding Protein Biomarkers through Placenta Proteome
Electrophoresis-Life Sciences Practical Applications (2018)
Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents
Yao J, et al.
Bioorganic & Medicinal Chemistry, 20(9), 2923-2929 (2012)
Isolation and Identification of Proteins From Potato Leaves
Szajko K
Plant Breeding, 75(1), 29-36 (2017)
Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells
Li J, et al.
Autophagy, 6(6), 711-724 (2010)
Capabilities using 2-D DIGE in proteomics research
Tissue proteomics, 1-18 (2008)
View All Related Papers

Articles

Components of Rehydration Solution

This page describes components of rehydration solutions for use in 2-D Electrophoresis with Cytiva products.

Protocols

Rehydration Solutions

This page describes typical rehydration solutions for use in gel electrophoresis with Cytiva products.

Two-Dimensional Separation of Protein Samples

This page describes two-dimensional separation of protein samples with Cytiva products.

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