Skip to Content

System maintenance is scheduled for 11 Sep, 08:00 PM - 12 Sep, 00:00 AM CST [12 Sep 03:00 AM to 07:00 AM CET] and will affect some web and offline transactions, including quotes, price checks, and order status inquiries. We apologize for any inconvenience.

Merck

Skip To

C8249

Cardamonin

≥98% (HPLC),  glycogen synthase kinase 3 (GSK3) inhibitor, powder

Promotion Available

Synonym(s):

(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one, (8CI); Alpinetin chalcone, (E)-2′,4′-Dihydroxy-6′-methoxy-chalcone

Sign In to View Organizational & Contract Pricing.

Spend €500 — Save 5%; Spend €700 — Save 10%; Spend €1,500 — Save 15%*

Sign in to check eligibility. Shop Products

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
€166.00
25 mg
Please contact Customer Service for Availability
€662.00

About This Item

Empirical Formula (Hill Notation):
C16H14O4
CAS Number:
Molecular Weight:
270.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

€166.00

Save Up To 15%


Please contact Customer Service for Availability

Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Product Name

Cardamonin, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

light yellow to dark brown

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

O=C(/C=C/C1=CC=CC=C1)C2=C(O)C=C(O)C=C2OC

InChI

1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+

InChI key

NYSZJNUIVUBQMM-BQYQJAHWSA-N

Application

Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.
Cardamonin has been used as a standard in high performance liquid chromatography (HPLC) to analyze phenolic compounds in acacia honey samples.

Biochem/physiol Actions

Cardamonin is a calchone from Aplinia species (zingiberaceous plant species).
Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
PHL80379681672SML1450
description

≥98% (HPLC)

description

phyproof® Reference Substance

description

The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer applications.

description

≥98% (HPCE)

form

powder

form

-

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPCE)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: ≥20 mg/mL

solubility

-

solubility

ethanol: 5 mg/mL, DMSO: 100 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

color

light yellow to dark brown

color

-

color

orange-yellow to amber

color

white to beige


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library




Questions

Reviews

No rating value

Active Filters