The stock solution should be stored at 0 - 4°C for short-term use or at -20°C for long-term storage.
C7397
Cyclophosphamide monohydrate
ISOPAC®
Synonym(s):
2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
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1 G
€144.00
About This Item
Empirical Formula (Hill Notation):
C7H15Cl2N2O2P · H2O
CAS Number:
Molecular Weight:
279.10
Beilstein:
4678992
EC Number:
MDL number:
UNSPSC Code:
51112507
PubChem Substance ID:
NACRES:
NA.25
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Quality Level
Assay
97.0-103.0% (HPLC)
form
powder
mp
49-51 °C (lit.)
storage temp.
2-8°C
SMILES string
[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1
InChI
1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
InChI key
PWOQRKCAHTVFLB-UHFFFAOYSA-N
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Application
Cyclophosphamide, a nitrogen mustard DNA alkylating agent, is used to study its mechanisms of action as an anticancer and antiimmunity drug.
Biochem/physiol Actions
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.
Packaging
Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.
Caution
Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.
Reconstitution
Dissolving the contents in 100 mL of solvent yields a 1% solution.
Legal Information
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
ISOPAC of
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Articles
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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How should stock solutions for item C7397-1G, Cyclophosphamide monohydrate be stored?
1 answer-
Helpful?
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what is the difference between C7397 & C0768?
1 answer-
Both Product C7397 and C0768 fall under the same Chemical Abstract Service number (CAS) 6055-19-2, which means chemically they are the same. Both products are also offered in a powdered format. These products are suitable for the application of cyclophosphamide.
The differences between the two materials is that product C7397 is only offered in 1 gram pack size. It is also apart of the ISOPAC portfolio, which are products that are packaged in special packaging for sensitive and hazardous chemical. This product is specifically packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal. This specialized packaging allows for injection of a compatible solvent directly into the vial to any desired strength solution without exposure of the material to the air. Product C0768 is offered in 1 gram, 5 grams, 10 grams, and 25 grams. All pack sizes are packaged in a glass bottle and bulk packaging is an available option for this material.
Product C7397 has a quality level of 100 while product C0768 has a quality level of 200. Products with quality level 100 are designed for non-regulated applications with no change notification requirements. Products with quality level of 200 are designed for non-regulated applications with limited change notification requirements.
The specifications for each product are slightly different as well, please view the specification sheets for both items:
https://www.sigmaaldrich.com/specification-sheets/473/595/C7397-BULK________SIGMA____.pdf
https://www.sigmaaldrich.com/specification-sheets/989/258/C0768-BULK________SIGMA____.pdfHelpful?
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