The solubility of Ceftazidime hydrate (C3809) is as follows: it is soluble at 50mg/mL in 0.1 M NaOH.
C3809
Ceftazidime hydrate
90.0-105.0%, contains ~10% sodium carbonate as stabilizer
Synonym(s):
1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum
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About This Item
Empirical Formula (Hill Notation):
C22H22N6O7S2 · xH2O
CAS Number:
Molecular Weight:
546.58 (anhydrous basis)
MDL number:
UNSPSC Code:
51284108
PubChem Substance ID:
NACRES:
NA.85
Recommended Products
Quality Level
Assay
90.0-105.0%
form
powder or crystals
contains
~10% sodium carbonate as stabilizer
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].CC(C)(O\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[n+]3ccccc3)=C(N2C1=O)C([O-])=O)c4csc(N)n4)C(O)=O
InChI
1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1...../s1
InChI key
NMVPEQXCMGEDNH-TZVUEUGBSA-N
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General description
Broad spectrum antibiotic; third generation cephalosporin
Chemical structure: ß-lactam
Application
Ceftazidime hydrate is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis. It is also used in bacterial susceptibility studies and to select mutant colonies of interest.
Used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cephalosporins, such as ceftazidime , disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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What is the recommended method for reconstituting the product C3809, Ceftazidime hydrate?
1 answer-
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What is the solution stability of the Product C3809, Ceftazidime hydrate?
1 answer-
Unfortunately, we do not test Product C3809, Ceftazidime hydrate, for solution stability. However, Chedru-Legros V. et al., Cornea, 29(7),807-11(2010), report 5% solutions of ceftazidime 0.9% sodium chloride can be stored at -20°C for 6 months. Also, Mehta, S. et al., Retina, 31(7),1316-22 (2011), reports single-use polypropylene syringes retain potency, sterility, and stability for 24 weeks when stored at -20°C or -80°C.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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