Cotrimoxazole has been used as an antimicrobial agent.[1][2]
Biochem/physiol Actions
Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.
Packaging
1ml
Preparation Note
prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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