A2201

Amyloid β-Protein Fragment 35-25

≥95% (HPLC)

• Empirical Formula (Hill Notation): C₄₅H₈₁N₁₃O₁₄S
• CAS Number: 147740-73-6
• Molecular Weight: 1060.27
• NACRES: NA.32
• PubChem Substance ID: 24890634
• UNSPSC Code: 51111800
• MDL number: MFCD00214225
• Form: powder
• Assay: ≥95% (HPLC)

Properties

• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: powder
• UniProt accession no.: P05067
• storage temp.: −20°C
• SMILES string: CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O
• InChI: 1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)
• InChI key: IDGOADDOQWKZOX-UHFFFAOYSA-N
• Gene Information: human ... APP(351)

Description

General description

Amyloid β precursor protein (APP) is a type-1 transmembrane protein.[1] APP is expressed widely and mainly found in the synapses and neurons.[2] The APP gene is mapped to human chromosome 21q21.3.[3]

Application

Amyloid β-Protein Fragment 35-25 has been used as a control peptide for Aβ-induced apoptosis to study the role of hepcidin overexpression in astrocytes against amyloid-β induced brain damage in mice.[4]

Biochem/physiol Actions

Proteolytic processing of amyloid β precursor protein (APP) forms the β amyloid protein (Aβ) as part of the brain amyloid plaques[1] which are the key biomarkers in Alzheimer′s disease. APP is known to be associated with neurogenesis, synapse formation, axonal transport, neuronal migration and neurite outgrowth. It is also related to mitochondria-associated endoplasmic reticulum membranes (MAMs) activity, antimicrobial protection, cholesterol, and iron homeostasis.[2][1] Amyloid β-Protein Fragment 35-25 is an inactive control.

Other Notes

The N—C inverted sequence of fragment 25-35

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)