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Roche

Mitomycin C

crystalline powder, 98%, pkg of 2 mg

Synonym(s):

Mitomycin C

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About This Item

Empirical Formula (Hill Notation):
C15H18N4O5
CAS Number:
50-07-7
Molecular Weight:
334.33
UNSPSC Code:
12352207

Quality Level

100

Assay

98%

form

crystalline powder

mol wt

334.3

packaging

pkg of 2 mg

manufacturer/tradename

Roche

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

DNA synthesis | interferes

storage temp.

2-8°C

InChI

1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChI key

NWIBSHFKIJFRCO-WUDYKRTCSA-N

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General description

Mitomycin C is an antitumor antibiotic.

Application

Mitomycin C has been used:
  • to cease mitosis
  • in phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)
  • as mutagen in mutagenicity assay

Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.

Biochem/physiol Actions

Mitomycin C (MMC) acts as a prototype for drugs with bioreductive alkylation. It is mainly found to be active under anaerobic conditions. MMC exhibits a vast clinical antitumor spectrum effectively in gastric, pancreatic and breast cancer.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H300,H351

Hazard Classifications

Acute Tox. 2 Oral - Carc. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

400046

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4-Nitroquinoline N-oxide ≥98%

Sigma-Aldrich

N8141

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Natalia Garcia-Becerra et al.
Cancers, 15(2) (2023-01-22)
Cervical cancer (CC) is the fourth most common type of cancer among women; the main predisposing factor is persistent infection by high-risk human papillomavirus (hr-HPV), mainly the 16 or 18 genotypes. Both hr-HPVs are known to manipulate the cellular machinery
Sertoli cell-mediated differentiation of bovine fetal mesenchymal stem cells into germ cell lineage using an in vitro co-culture system
Segunda MN, et al.
Theriogenology, 130, 8-18 (2019)
Renato B Baleeiro et al.
Oncoimmunology, 11(1), 2080329-2080329 (2022-06-04)
MHC class II expression is a hallmark of professional antigen-presenting cells and key to the induction of CD4+ T helper cells. We found that these molecules are ectopically expressed on tumor cells in a large proportion of patients with pancreatic
Jeremy Setton et al.
NPJ breast cancer, 7(1), 135-135 (2021-10-13)
Pathogenic germline mutations in the RAD51 paralog genes RAD51C and RAD51D, are known to confer susceptibility to ovarian and triple-negative breast cancer. Here, we investigated whether germline loss-of-function variants affecting another RAD51 paralog gene, RAD51B, are also associated with breast
M Tomasz
Chemistry & biology, 2(9), 575-579 (1995-09-01)
Mitomycin C, an important antitumor drug and antibiotic, has an extraordinary ability to crosslink DNA with high efficiency and absolute specificity for the sequence CpG. Recent results have shown how mitomycin C crosslinks DNA, and why the sequence specificity is
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