Matriptase-2/TMPRSS6, also known as Transmembrane protease serine 6, and encoded by the gene TMPRSS6, is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen and appears to play an important role in matrix remodeling in the liver. Matriptase-2/TMPRSS6 also plays an important role in iron homeostasis and interacts with the iron homeostasis protein Hepcidin. Maintaining the body’s levels of iron within precise boundaries is essential for normal physiological function. Alterations of these levels below or above the healthy limit lead to a systemic deficiency or overload in iron. Matriptase-2/TMPRSS6 is a proteolytic regulator of iron homeostasis. Matriptase-2/TMPRSS6 is expressed only in the liver in normal tissues and undergoes proteolytic processing to yield two activated chains that are shed one intracellularly and one extracellularly. Mutations in Matriptase-2/TMPRSS6 gene give rise to iron deficiency anemia.
Immunogen
Epitope: Near C-terminal
GST-tagged recombinant protein corresponding to human Matriptase-2/TMPRSS6 near the C-terminal.
Application
Anti-Matriptase-2/TMPRSS6 Antibody is an antibody against Matriptase-2/TMPRSS6 for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Matriptase-2/TMPRSS6 in human liver and mouse liver tissue.
Research Category Cell Structure
Research Sub Category Adhesion (CAMs)
Quality
Evaluated by Western Blotting in MCF-7 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Matriptase-2/TMPRSS6 in 10 µg of MCF-7 cell lysate.
Target description
~52 kDa observed
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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