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648471

Trolox

A cell-permeable, water-soluble derivative of vitamin E with antioxidant properties. Prevents peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.

Synonym(s):

Trolox, 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid

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About This Item

Empirical Formula (Hill Notation):
C14H18O4
CAS Number:
53188-07-1
Molecular Weight:
250.29
MDL number:
MFCD00006846
UNSPSC Code:
12352205
Pricing and availability is not currently available.

description

RTECS - DJ2273000

Assay

≥98% (titration)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white
 white to pale green
 white to pale yellow

solubility

water: 0.5 mg/mL (slightly soluble)
ethanol: 150 mg/mL
methanol: soluble

shipped in

ambient

storage temp.

2-8°C

SMILES string

O1C(CCc2c1c(c(c(c2C)O)C)C)(C)C(=O)O

InChI

1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)

InChI key

GLEVLJDDWXEYCO-UHFFFAOYSA-N

General description

A cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. Prevents peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.

Application


  • Structural characterization of peroxyl radical oxidative products of antioxidant peptides from hydrolyzed proteins.: This study highlights the application of Trolox in understanding the oxidative modifications of antioxidant peptides, which could help in the development of more effective antioxidative therapies and supplements (Esfandi et al., 2024).

  • Extraction of bioactive compounds from pecan nutshell: An added-value and low-cost alternative for an industrial waste.: Trolox is utilized to evaluate the antioxidant capacity of bioactive extracts from pecan shells, presenting a sustainable approach to utilizing agricultural waste (Cardona Jimenez et al., 2024).

  • Investigation into the role of carboxylic acid and phenolic hydroxyl groups in the plant biostimulant activity of a humic acid purified from an oxidized sub-bituminous coal.: Utilizing Trolox equivalent antioxidant capacity (TEAC) assay, this research explores the bio-stimulatory properties of humic substances, enhancing our understanding of their role in agriculture (Lamar et al., 2024).

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.

Other Notes

Salgo, M.G. and Pryor, W.A. 1996. Arch. Biochem. Biophys. 333, 482.
McClain, D.E., et al. 1995. FASEB J. 9, 1345.
Salgo, M.G., et al. 1995. Arch. Biochem. Biophys.322, 500.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Meriam Missaoui et al.
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Refat Aboghazleh et al.
International journal of molecular sciences, 22(21) (2021-11-14)
Traumatic brain injury (TBI) is the leading cause of death in young individuals, and is a major health concern that often leads to long-lasting complications. However, the electrophysiological events that occur immediately after traumatic brain injury, and may underlie impact
Saravanan Palani et al.
eLife, 10 (2021-07-17)
Actin filaments are central to numerous biological processes in all domains of life. Driven by the interplay with molecular motors, actin binding and actin modulating proteins, the actin cytoskeleton exhibits a variety of geometries. This includes structures with a curved
Ying-Nan Jiang et al.
Journal of ethnopharmacology, 256, 112824-112824 (2020-04-08)
Tianma Gouteng granules (TG), a clinical prescription of traditional Chinese medicine, has been clinically applied to treat Parkinson's disease (PD) in combination with Madopar, as included in the Chinese Pharmacopoeia (2015). TG has the potential to decrease the susceptibility of
Saara Hämälistö et al.
Nature communications, 11(1), 229-229 (2020-01-15)
Lysosomes are membrane-surrounded cytoplasmic organelles filled with a powerful cocktail of hydrolases. Besides degrading cellular constituents inside the lysosomal lumen, lysosomal hydrolases promote tissue remodeling when delivered to the extracellular space and cell death when released to the cytosol. Here

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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