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T-018

Supelco

(−)-11-nor-9-Carboxy-Δ9-THC solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C21H28O4
CAS Number:
56354-06-4
Molecular Weight:
344.44
EC Number:
200-659-6
MDL number:
MFCD02682121
UNSPSC Code:
41116107
PubChem Substance ID:
329826589
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

suitability

suitable for immunoassay

application(s)

cannabis testing
forensics and toxicology

format

single component solution

storage temp.

2-8°C

SMILES string

CCCCCC(C=C1O)=CC2=C1[C@@]3([H])[C@@](C(C)(C)O2)([H])CCC(C(O)=O)=C3

InChI

1S/C21H28O4/c1-4-5-6-7-13-10-17(22)19-15-12-14(20(23)24)8-9-16(15)21(2,3)25-18(19)11-13/h10-12,15-16,22H,4-9H2,1-3H3,(H,23,24)/t15-,16-/m1/s1

InChI key

YOVRGSHRZRJTLZ-HZPDHXFCSA-N

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General description

An analytical reference standard suitable in cannabinoid testing, clinical toxicology, forensic analysis, or urine drug testing by LC-MS/MS or GC/MS. Also known as THC acid, 11-nor-9-Carboxy-Δ9-THC is the main secondary metabolite of THC found in urine or blood of cannabis users.

Application

  • Advanced analytical method development: A study by DeGregorio et al. introduces a Liquid Chromatography High-Resolution Mass Spectrometry (LC-HRMS) bioanalytical method for quantifying cannabinoids, including (−)-11-nor-9-Carboxy-Δ?-THC, in whole blood. This method is pivotal for determining recent cannabis use, offering significant advancements in forensic toxicology and drug testing (DeGregorio et al., 2020).
  • Cannabinoid serum analysis: Gottardo et al. present the first application of atmospheric-pressure chemical ionization gas chromatography tandem mass spectrometry for the determination of cannabinoids in serum. This groundbreaking technique enhances the detection and quantification of cannabinoids, including (−)-11-nor-9-Carboxy-Δ?-THC, facilitating deeper insights into cannabinoid pharmacokinetics and toxicology (Gottardo et al., 2019).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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T-007

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T-008

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T-011

(−)-Δ9-THC-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

T-019

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T-038

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T-080

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Vanessa de M Prata et al.
Analytical and bioanalytical chemistry, 403(2), 625-632 (2012-03-01)
A new procedure is described for the derivatization by silylation of 11-nor-Δ(9)-tetrahydrocannabinol-9-carboxylic acid (THCCOOH) present in urine, followed by analysis using gas chromatography-tandem mass spectrometry. A conventional procedure for derivatization of the analyte was evaluated using two types of experimental
Cynthia Coulter et al.
Journal of analytical toxicology, 36(6), 413-417 (2012-04-26)
This paper describes the determination of tetrahydrocannabinol (THC) and its metabolite, 11-nor-Δ⁹-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in oral fluid using solid-phase extraction and liquid chromatography with tandem mass spectral detection (LC-MS-MS) and its application to proficiency specimens. The method employs collection of
M Minoli et al.
Forensic science international, 218(1-3), 49-52 (2011-11-01)
The fine detection of 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid (THCCOOH) in hair matrix remains one of the most important topics in hair analysis. This relevance lies in the necessity to obtain evidence of effective drug consumption and dispel any doubt of environmental contamination.
Andreas R Baudy et al.
The Journal of pharmacology and experimental therapeutics, 343(1), 225-232 (2012-06-30)
Glucocorticoids are standard of care for many inflammatory conditions, but chronic use is associated with a broad array of side effects. This has led to a search for dissociative glucocorticoids--drugs able to retain or improve efficacy associated with transrepression [nuclear
Caroline Bylda et al.
Drug testing and analysis, 4(7-8), 668-674 (2012-03-01)
A fast and sensitive reference method for quantification of Δ(9) -tetrahydrocannabinol (THC) and its main metabolite 11-nor-9-carboxy-Δ(9) -tetrahydrocannabinol (THCCOOH) in oral fluid is described in this study. Samples were collected using an oral specimen collection device, followed by solid-phase extraction
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