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D152803

Sigma-Aldrich

Dimethylcarbamyl chloride

98%

Synonym(s):

Chloroformic acid dimethyl amide, Dimethylcarbamoyl chloride

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5 G
€19.10
100 G
€37.40
500 G
€122.00

About This Item

Linear Formula:
(CH3)2NCOCl
CAS Number:
Molecular Weight:
107.54
Beilstein:
878197
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

€19.10


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Assay

98%

form

liquid

refractive index

n20/D 1.453 (lit.)

bp

167-168 °C/775 mmHg (lit.)

mp

−33 °C (lit.)

density

1.168 g/mL at 25 °C (lit.)

SMILES string

CN(C)C(Cl)=O

InChI

1S/C3H6ClNO/c1-5(2)3(4)6/h1-2H3

InChI key

YIIMEMSDCNDGTB-UHFFFAOYSA-N

Application

Dimethylcarbamyl chloride can be used to synthesize:
  • Disubstituted carbamates from benzylphenols.[1]
  • 2-Cyanoisonicotinamide by reacting with isonicotinic acid N-oxide and zinc cyanide. This method was adopted to synthesize a novel xanthine oxidoreductase inhibitor.[2]
  • Acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors.[3]

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

179.6 °F - closed cup

Flash Point(C)

82 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number

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Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease.
Kogen H, et al.
Organic Letters, 4(20), 3359-3362 (2002)
S J Garte et al.
Environmental health perspectives, 81, 29-31 (1989-05-01)
Techniques of molecular biology have been used to determine the relationship of cellular oncogenes to mechanisms of experimental carcinogenesis. Model systems involving three direct-acting alkylating carcinogens, two organ sites, and two species have been employed to elucidate the relationships between
A E Hochwalt et al.
Molecular carcinogenesis, 1(1), 4-6 (1988-01-01)
Rat nasal squamous cell carcinomas induced by inhalation of three direct-acting alkylating agents yielded DNA containing activated oncogenes with no homology to any member of the ras family. The novel NIH 3T3 transforming oncogenes from tumors induced by beta-propiolactone and
C A Snyder et al.
Archives of toxicology, 61(1), 3-6 (1987-01-01)
A new inhalation exposure system has been developed which allows the determination of inhaled doses of vapors and gases by laboratory rats. The system consists of saran bags connected to head-only exposure cylinders via one-way valves. One bag serves as
Dimethylcarbamoyl chloride.
IARC monographs on the evaluation of carcinogenic risks to humans, 71 Pt 2, 531-543 (1999-09-07)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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