The Journal of biological chemistry, 286(51), 43913-43924 (2011-10-29)
Ivermectin is an anthelmintic drug that works by activating glutamate-gated chloride channel receptors (GluClRs) in nematode parasites. GluClRs belong to the Cys-loop receptor family that also includes glycine receptor (GlyR) chloride channels. GluClRs and A288G mutant GlyRs are both activated
Journal of medicinal chemistry, 56(12), 5059-5070 (2013-05-31)
We recently designed a group of novel exosite-2-directed sulfated, small, allosteric inhibitors of thrombin. To develop more potent inhibitors, monosulfated benzofuran tri- and tetrameric homologues of the parent designed dimers were synthesized in seven to eight steps and found to
Chemical communications (Cambridge, England), 47(43), 11957-11959 (2011-10-05)
The concentration quenching threshold of upconversion luminescence was broken through for the first time via a designed strategy: spatial separation of the emitter doping area.
Highly diastereoselective multicomponent cascade reactions: efficient synthesis of functionalized 1-indanols.
Jun Jiang et al.
Angewandte Chemie (International ed. in English), 52(5), 1539-1542 (2013-01-03)
The Journal of organic chemistry, 77(15), 6473-6479 (2012-07-11)
2-Substituted benzo[b]furans were synthesized by a one-step metal-free photochemical reaction between 2-chlorophenol derivatives and terminal alkynes by tandem formation of an aryl-C and a C-O bond via an aryl cation intermediate. The mild conditions and the application to chlorophenols rather
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