915823
Fmoc-Cys(2,4-hexadiene)-OH
≥95%
Synonym(s):
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-((2E,4E)-hexa-2,4-dien-1-yl)-L-cysteine, Diene-containing cysteine for peptide macrocylization
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About This Item
Empirical Formula (Hill Notation):
C24H25NO4S
Molecular Weight:
423.52
UNSPSC Code:
12352209
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Assay
≥95%
form
solid
mp
91-96 °C
storage temp.
−20°C
Application
Fmoc-Cys(2,4-hexadiene)-OH is a diene-containing amino acid developed in the Moellering lab for the preparation of Diels-Alder-cyclized peptides for macrocyclization and peptide stabilization. Peptide macrocycles are of increasing interest for improving peptide bioactivity and properties as well as their potential to study, stabilize, or inhibit protein-protein interactions (PPIs).
related product
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Jeffrey E Montgomery et al.
Journal of the American Chemical Society, 141(41), 16374-16381 (2019-09-17)
Macrocyclization can improve bioactive peptide ligands through preorganization of molecular topology, leading to improvement of pharmacologic properties like binding affinity, cell permeability, and metabolic stability. Here we demonstrate that Diels-Alder [4 + 2] cycloadditions can be harnessed for peptide macrocyclization
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