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797529

Sigma-Aldrich

tert-Butyl 3-hydroxy-1-oxa-6-azaspiro[3.3]heptane-6-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C10H17NO4
CAS Number:
1349199-63-8
Molecular Weight:
215.25
MDL number:
MFCD22370059
UNSPSC Code:
12352100
PubChem Substance ID:
329768606

form

liquid

storage temp.

2-8°C

SMILES string

OC1C2(CN(C(OC(C)(C)C)=O)C2)OC1

InChI

1S/C10H17NO4/c1-9(2,3)15-8(13)11-5-10(6-11)7(12)4-14-10/h7,12H,4-6H2,1-3H3

InChI key

BFXOBAHLWARETK-UHFFFAOYSA-N

Application

Spirocyclic building block is part of a series of advanced angular[3.3]heptanes developed by Carreira and coworkers

Other Notes

Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Articles

Spirocyclic Building Blocks for Scaffold Assembly

Spirocyclic modules containing four-membered rings are currently of growing interest to discovery chemists.

Related Content

Carreira Group – Professor Product Portal

The Carreira Research Group is focused on expanding and creating access to uncharted landscape in chemical space. In joint efforts with SpiroChem, Carreira develops innovative spirocyclic building blocks, seeking to make them available to the community at large. Molecules constructed from these building blocks take on unique three-dimensional profiles due to the underlying spirocyclic scaffold, enriched by the presence of diverse combinations of exit vectors as sites for functionalization. Importantly, the spirocyclic building blocks possess physicochemical properties useful in the drug discovery process. Thus, drug leads can be tuned through appending these subunits to the periphery of a given scaffold. Moreover, these compact modules represent a useful collection of unprecedented inputs for fragment-based libraries. In all applications, the inherent novelty of the structure affords researchers new opportunities to run wild in their designs and avenues to chemical space – with their imagination as the sole limitations. We are proud to partner in the efforts to make these building blocks widely available.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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