- Altered expression and modulation of the two-pore-domain (K
Altered expression and modulation of the two-pore-domain (K
American journal of physiology. Renal physiology (2017-05-26)
Ricardo H Pineda, Balachandar Nedumaran, Joseph Hypolite, Xiao-Qing Pan, Shandra Wilson, Randall B Meacham, Anna P Malykhina
PMID28539337
ABSTRACT
Detrusor overactivity (DO) is the abnormal response of the urinary bladder to physiological stretch during the filling phase of the micturition cycle. The mechanisms of bladder smooth muscle compliance upon the wall stretch are poorly understood. We previously reported that the function of normal detrusor is regulated by TREK-1, a member of the mechanogated subfamily of two-pore-domain potassium (K
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