- Plant Polyphenols and Exendin-4 Prevent Hyperactivity and TNF-α Release in LPS-Treated
Plant Polyphenols and Exendin-4 Prevent Hyperactivity and TNF-α Release in LPS-Treated
Frontiers in neuroscience (2017-09-22)
Francesca Gullo, Michela Ceriani, Alessia D'Aloia, Enzo Wanke, Andrew Constanti, Barbara Costa, Marzia Lecchi
PMID28932183
ABSTRACT
Increasing evidence supports a decisive role for neuroinflammation in the neurodegenerative process of several central nervous system (CNS) disorders. Microglia are essential mediators of neuroinflammation and can regulate a broad spectrum of cellular responses by releasing reactive oxygen intermediates, nitric oxide, proteases, excitatory amino acids, and cytokines. We have recently shown that also in
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