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  • Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesis.

Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesis.

European journal of biochemistry (1979-09-01)
S Perzynski, M Cannon, E Cundliffe, S B Chahwala, J Davies
PMID115690
ABSTRACT

1. The novel aminoglycoside antibiotic apramycin is shown to be a potent inhibitor of protein synthesis in bacteria both in vivo and in vitro. 2. In cell-free systems from Escherichia coli programmed with poly(U), apramycin induces translation errors, as assayed by incorporation of leucine, isoleucine and serine, although this effect occurs only to a limited extent. 3. Apramycin inhibits the translocation step of protein synthesis both in vivo, in protoplasts of Bacillus megaterium, and in vitro, in cell-free systems from E. coli. It is proposed that this is the primary inhibitory effect of the drug.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Apramycin sulfate salt