- Highly enantioselective catalytic acyl-pictet-spengler reactions.
Highly enantioselective catalytic acyl-pictet-spengler reactions.
Journal of the American Chemical Society (2004-08-26)
Mark S Taylor, Eric N Jacobsen
PMID15327311
ABSTRACT
The enantioselective cyclization of N-acyliminium ions generated in situ from tryptamine is promoted with high enantioselectivity by a new chiral thiourea catalyst. This represents the first successful system for asymmetric catalysis of the Pictet-Spengler reaction.