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Biphasic Synthesis of Large-Pore and Well-Dispersed Benzene Bridged Mesoporous Organosilica Nanoparticles for Intracellular Protein Delivery.

Biphasic Synthesis of Large-Pore and Well-Dispersed Benzene Bridged Mesoporous Organosilica Nanoparticles for Intracellular Protein Delivery.

Small (Weinheim an der Bergstrasse, Germany) (2015-02-06)

Yannan Yang, Yuting Niu, Jun Zhang, Anand Kumar Meka, Hongwei Zhang, Chun Xu, Chun Xiang Cynthia Lin, Meihua Yu, Chengzhong Yu

ABSTRACT

Large pore (4.6-7.6 nm) and well-dispersed benzene bridged mesoporous organosilica nanoparticles with uniform particle size of ≈50 nm are prepared via a biphasic approach. They can be directly used as nanocarriers without surface modification for the intracellular delivery of therapeutic proteins.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Isopropyl alcohol, ≥99.7%, FCC, FG

Sigma-Aldrich

2-Propanol, suitable for HPLC

Sigma-Aldrich

2-Propanol, JIS special grade, ≥99.5%

Sigma-Aldrich

Toluene, SAJ first grade, ≥99.0%

Sigma-Aldrich

Triethanolamine, JIS special grade, ≥98.0%

Sigma-Aldrich

Toluene, JIS 300, for residue analysis, ≥99.8%

Sigma-Aldrich

Toluene, JIS 1000, for residue analysis, ≥99.8%

Sigma-Aldrich

2-Propanol, SAJ first grade, ≥99.0%

Sigma-Aldrich

Toluene, suitable for HPLC, ≥99.9%

Sigma-Aldrich

2-Propanol, electronic grade, 99.999% trace metals basis

Sigma-Aldrich

2-Propanol, BioUltra, for molecular biology, ≥99.5% (GC)

Sigma-Aldrich

Toluene, JIS special grade, ≥99.5%

Sigma-Aldrich

2-Propanol, anhydrous, 99.5%

Supelco

Toluene, HPLC grade, 99.8%

Sigma-Aldrich

2-Propanol, 99.5%, HPLC grade

Sigma-Aldrich

Triethanolamine, BioUltra, ≥99.5% (GC)

Sigma-Aldrich

Triethanolamine, ≥99.0% (GC)

Sigma-Aldrich

Triethanolamine, puriss. p.a., ≥99% (GC)

Sigma-Aldrich

Toluene, anhydrous, 99.8%

Sigma-Aldrich

2-Propanol, ACS reagent, ≥99.5%

Sigma-Aldrich

DAPI, for nucleic acid staining

Sigma-Aldrich

2-Propanol, for molecular biology, BioReagent, ≥99.5%

Sigma-Aldrich

2-Propanol, HPLC Plus, for HPLC, GC, and residue analysis, 99.9%, poly coated bottles

Sigma-Aldrich

Triethanolamine, reagent grade, 98%