- Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
Proceedings of the National Academy of Sciences of the United States of America (1978-11-01)
D Solter, B B Knowles
PMID281705
ABSTRACT
A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described. This antibody, which reacts with embryonal carcinoma cells of mouse and human origin and with some preimplantation stage mouse embryos, defines an embryonic stage-specific antigen. This stage-specific antigen (SSEA-1) is first detected on blastomeres of 8-cell stage embryos. Trophectodermal cells are transitorily positive; however, each cell in the inner cell mass eventually expresses this antigen.
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Dulbecco′s Modified Eagle′s Medium - low glucose, With 1000 mg/L glucose and L-glutamine, without sodium bicarbonate and phenol red, powder, suitable for cell culture