Skip to Content
MilliporeSigma

The role of iron in brain ageing and neurodegenerative disorders.

The Lancet. Neurology (2014-09-19)
Roberta J Ward, Fabio A Zucca, Jeff H Duyn, Robert R Crichton, Luigi Zecca
ABSTRACT

In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation and modification of lipids, proteins, carbohydrates, and DNA. During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. In various neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, changes in iron homoeostasis result in altered cellular iron distribution and accumulation. MRI can often identify these changes, thus providing a potential diagnostic biomarker of neurodegenerative diseases. An important avenue to reduce iron accumulation is the use of iron chelators that are able to cross the blood-brain barrier, penetrate cells, and reduce excessive iron accumulation, thereby affording neuroprotection.

MATERIALS
Product Number
Brand
Product Description

Iron, foil, not light tested, 50x50mm, thickness 0.001mm, 99.85%
Iron, wire reel, 50m, diameter 0.25mm, hard, 99.5%
Iron, wire reel, 1m, diameter 1.0mm, as drawn, 99.99+%
Iron, wire reel, 0.5m, diameter 0.25mm, hard, 99.99+%
Iron, wire reel, 1m, diameter 0.5mm, as drawn, 99.998%
Iron, foil, 25x25mm, thickness 1.0mm, as rolled, 99.5%
Iron, foil, not light tested, 50x50mm, thickness 0.003mm, 99.85%
Iron, rod, 100mm, diameter 10.0mm, as drawn, 99.99+%
Iron, foil, not light tested, 50x50mm, thickness 0.0025mm, 99.85%
Iron, rod, 100mm, diameter 50mm, as drawn, armcO« soft ingot 99.8%
Iron, foil, not light tested, 25x25mm, thickness 0.002mm, 99.85%
Iron, foil, light tested, 100x100mm, thickness 0.05mm, as rolled, 99.99+%
Iron, foil, 100x100mm, thickness 2.0mm, as rolled, 99.95%
Iron, foil, 8mm disks, thickness 0.075mm, hard, 99.5%
Iron, rod, 1000mm, diameter 3.2mm, as drawn, 98+%
Iron, rod, 50mm, diameter 5.0mm, as drawn, 99.99+%
Iron, foil, 100x100mm, thickness 0.125mm, hard, 99.5%
Iron, foil, 15mm disks, thickness 0.0125mm, 99.85%
Iron, foil, 4mm disks, thickness 0.009mm, 99.85%
Iron, foil, 1m coil, thickness 0.1mm, hard, 99.5%
Iron, foil, 25mm disks, thickness 1.0mm, as rolled, 99.5%
Iron, foil, 25mm disks, thickness 0.020mm, 99.85%
Iron, foil, 2m coil, thickness 0.038mm, hard, 99.5%
Iron, foil, 15mm disks, thickness 0.125mm, hard, 99.5%
Iron, foil, 15mm disks, thickness 0.006mm, 99.85%
Iron, foil, 10mm disks, thickness 0.38mm, hard, 99.5%
Iron, foil, 15mm disks, thickness 0.020mm, 99.85%
Iron, foil, 25mm disks, thickness 0.125mm, hard, 99.5%
Iron, foil, 10mm disks, thickness 0.9mm, as rolled, 99.5%
Iron, foil, 1m coil, thickness 0.38mm, hard, 99.5%