Mitomycin C in the treatment of keloids: a case and review.

Mitomycin C in the treatment of keloids: a case and review.

Journal of drugs in dermatology : JDD (2013-07-11)

Rebecca Kleinerman, Suzanne L Kilmer, Vera A Chotzen

ABSTRACT

Mitomycin C (MMC) is an antineoplastic antibiotic that has been used off-label in the treatment of hypertrophic scars and keloids. Herein we report our successful use of this agent in a patient with sternal keloids refractory to other means of therapy. We further review the literature regarding the use of MMC in the treatment of keloids.

MATERIALS

Product Number

Brand

Product Description

Y0000378

Mitomycin, European Pharmacopoeia (EP) Reference Standard

M7949

Sigma-Aldrich

Mitomycin C from Streptomyces caespitosus, ≥98% (HPLC), potency: ≥970 μg per mg (USP XXIV), γ-irradiated, suitable for cell culture

M0440

Sigma-Aldrich

Mitomycin C from Streptomyces caespitosus, meets USP testing specifications

M4287

Sigma-Aldrich

Mitomycin C from Streptomyces caespitosus, powder, BioReagent, suitable for cell culture

M0503

Sigma-Aldrich

Mitomycin C from Streptomyces caespitosus, powder, contains NaCl as solubilizer