Nanocoating of titanium implant surfaces with organic molecules. Polysaccharides including glycosaminoglycans.

Nanocoating of titanium implant surfaces with organic molecules. Polysaccharides including glycosaminoglycans.

Journal of biomedical nanotechnology (2012-10-04)

Katarzyna Gurzawska, Rikke Svava, Niklas Rye Jørgensen, Klaus Gotfredsen

ABSTRACT

Long-term stability of titanium implants are dependent on a variety of factors. Nanocoating with organic molecules is one of the method used to improve osseointegration. Nanoscale modification of titanium implants affects surface properties, such as hydrophilicity, biochemical bonding capacity and roughness. This influences cell behaviour on the surface such as adhesion, proliferation and differentiation of cells as well as the mineralization of the extracellular matrix at the implant surfaces. The aim of the present systematic review was to describe organic molecules used for surface nanocoating with focus on polysaccharides including glycosaminoglycans, and how these molecules change surface properties, cell reactions and affect on osseointegartion. The included in vitro studies demonstrated increased cell adhesion, proliferation and mineralization of a number of the tested polysaccharide nanocoatings. The included in vivo studies, showed improvement of bone interface reactions measured as increased Bone-to-Implant Contact length and Bone Mineral Density adjacent to the polysaccharide coated surfaces. Based on existing literature, surface modification with polysaccharide and glycosaminoglycans appears to be an effective way to stimulate bone regeneration on bone-implant interface.

MATERIALS

Product Number

Brand

Product Description

IRMM531B

Titanium, IRMM^®, certified reference material, 0.5 mm foil

348791

Sigma-Aldrich

Titanium, foil, thickness 0.127 mm, 99.7% trace metals basis

266035

Sigma-Aldrich

Titanium, wire, diam. 1.0 mm, 99.99% trace metals basis

IRMM531C

Titanium, IRMM^®, certified reference material, 0.5 mm wire

369489

Sigma-Aldrich

Titanium, foil, thickness 2.0 mm, 99.7% trace metals basis

267902

Sigma-Aldrich

Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis

460400

Sigma-Aldrich

Titanium, wire, diam. 0.25 mm, 99.7% trace metals basis

305812

Sigma-Aldrich

Titanium, 5-10 mm, ≥99.99% trace metals basis (purity exclusive of Na and K content)

348848

Sigma-Aldrich

Titanium, foil, thickness 0.025 mm, 99.98% trace metals basis

GF65336700

Titanium, rod, 200mm, diameter 2mm, annealed, 99.6+%

GF76772391

Titanium, rod, 100mm, diameter 10mm, annealed, 99.6+%

GF87716997

Titanium, rod, 100mm, diameter 16mm, as drawn, 99.99+%

GF06082286

Titanium, microfoil, disks, 10mm, thinness 1.0μm, specific density 429μg/cm², permanent mylar 3.5μm support, 99.6+%

GF03916290

Titanium, rod, 490mm, diameter 2mm, annealed, 99.6+%

GF68670366

Titanium, tube, 1220mm, outside diameter 2.03mm, inside diameter 1.55mm, wall thickness 0.24mm, annealed, 99.6+%

GF82517722

Titanium, tube, 1000mm, outside diameter 6.35mm, inside diameter 4.57mm, wall thickness 0.89mm, annealed, 99.6+%

GF50171318

Titanium, rod, 25mm, diameter 16mm, as drawn, 99.99+%

GF03838282

Titanium, rod, 500mm, diameter 1.5mm, annealed, 99.6+%

GF04311638

Titanium, rod, 100mm, diameter 6mm, annealed, 99.6+%

GF25290581

Titanium, tube, 1000mm, outside diameter 25.4mm, inside diameter 23.62mm, wall thickness 0.89mm, annealed, 99.6+%

GF20882998

Titanium, rod, 200mm, diameter 5mm, annealed, 99.6+%

GF65694426

Titanium, tube, 100mm, outside diameter 1.6mm, inside diameter 1.2mm, wall thickness 0.2mm, hard, 99.6+%

GF54978249

Titanium, rod, 200mm, diameter 4mm, annealed, 99.6+%

GF34106363

Titanium, rod, 1000mm, diameter 1.5mm, annealed, 99.6+%

GF12929744

Titanium, microfoil, disks, 25mm, thinness 0.25μm, specific density 112.6μg/cm², permanent mylar 3.5μm support, 99.6+%

GF72503827

Titanium, tube, 100mm, outside diameter 2.03mm, inside diameter 1.63mm, wall thickness 0.2mm, annealed, 99.6+%

GF69259315

Titanium, rod, 500mm, diameter 6mm, annealed, 99.6+%

GF62676759

Titanium, rod, 200mm, diameter 2mm, as drawn, 99.99+%

GF85496664

Titanium, tube, 1000mm, outside diameter 9.5mm, inside diameter 8.2mm, wall thickness 0.65mm, annealed, 99.6+%

GF28411703

Titanium, tube, 100mm, outside diameter 10.3mm, inside diameter 8.7mm, wall thickness 0.8mm, annealed, 99.6+%