- Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.
Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.
Journal of inorganic biochemistry (2011-11-22)
Joseph Lemire, Vasu D Appanna
PMID22099161
ABSTRACT
Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.
MATERIALS
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Product Description
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Aluminum, IRMM®, certified reference material, 1.0 mm wire
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Aluminum, IRMM®, certified reference material, 1.0 mm foil
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Sigma-Aldrich
Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
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Aluminum, wire reel, 5m, diameter 2.0mm, as drawn, 99.999%
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Aluminum, wire reel, 5m, diameter 0.25mm, as drawn, 99.999%
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Aluminum, wire reel, 50m, diameter 0.25mm, hard, 99.99+%
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Aluminum, wire reel, 5m, diameter 0.025mm, as drawn, 99.99+%
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Aluminum, wire reel, 5m, diameter 0.025mm, as drawn, 99.0+%
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Aluminum, honeycomb, 300x300mm, thickness 5mm, cell size 13mm, cell wall 0.1mm, core density 0.062g/cm3, phenolic adhesive (resin), 99.5%
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Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 2 pores/cm, aluminum 6101 grade, 98.5%
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Aluminum, honeycomb, 600x600mm, thickness 20mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm3, phenolic adhesive (resin), 99.5%
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Aluminum, honeycomb, 300x300mm, thickness 13.9mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%
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Aluminum, microleaf disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm2, removable support, 99.999%
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Aluminum, tube, 0.1m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
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Aluminum, insulated wire, 20m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
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Aluminum, rod, 100mm, diameter 20.0mm, as drawn, 99.999%
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Aluminum, rod, 500mm, diameter 15.0mm, as drawn, 99.999%
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Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%
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Aluminum, tube, 2m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
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Aluminum, insulated wire, 2m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
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Aluminum, tube, 1000mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%
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Aluminum, sphere, 100pcs, diameter 2.5mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%
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Aluminum, rod, 200mm, diameter 15.0mm, as drawn, 99.999%
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Aluminum, rod, 500mm, diameter 5.0mm, as drawn, 99.999%
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Aluminum, rod, 200mm, diameter 20.0mm, as drawn, 99.999%
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