- [Updates on rickets and osteomalacia: various roles of Klotho and FGF23 in vivo ].
[Updates on rickets and osteomalacia: various roles of Klotho and FGF23 in vivo ].
Clinical calcium (2013-10-01)
Akihiro Imura
PMID24076646
ABSTRACT
Recent understandings of phosphate regulation have, at least in part, depended upon the findings of fibroblast growth factor (FGF) 23, the hormone specific for phosphate regulation. Moreover, FGF23 would be the most important marker for prognosis in chronic kidney disease (CKD) . On the other hand, Klotho was firstly developed as a responsible gene for senescence. Although the role of Klotho has been so far established as a co-receptor for FGF23 in mineral metabolism, Klotho would play rather various roles than FGF23 signaling. Thus Klotho is not necessarily equivalent to FGF23. Further studies for both Klotho and FGF23 will elucidate to understand mineral homeostasis.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type H-1, partially purified powder, ≥300,000 units/g solid
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type H-5, lyophilized powder, ≥400,000 units/g solid
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type HP-2S, aqueous solution, ≥90,000 units/mL
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type H-3AF, aqueous solution, ≥60,000 units/mL
Sigma-Aldrich
β-Glucuronidase from Helix pomatia, Type HP-2, aqueous solution, ≥100,000 units/mL
Sigma-Aldrich
β-Glucuronidase from limpets (Patella vulgata), Type L-II, lyophilized powder, 1,000,000-3,000,000 units/g solid
Sigma-Aldrich
β-Glucuronidase from limpets (Patella vulgata), aqueous solution, ≥85,000 units/mL
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, ≥10,000,000 units/g protein (30 min assay), recombinant, expressed in E. coli overproducing strain, lyophilized powder
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, >20,000,000 units/g protein, recombinant, expressed in E. coli, aqueous glycerol solution
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, ≥20,000 units/mg protein, recombinant, expressed in E. coli overproducing strain, lyophilized powder
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, Type IX-A, lyophilized powder, 1,000,000-5,000,000 units/g protein (30 min assay)
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, aqueous glycerol solution, ≥5,000,000 units/g protein, pH 6.8 (biuret)
Sigma-Aldrich
β-Glucuronidase from Escherichia coli, Type VII-A, lyophilized powder, 5,000,000-20,000,000 units/g protein, pH 6.8 (30 min assay)