- Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity.
Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity.
Biological & pharmaceutical bulletin (1997-10-23)
S Hamada, T Kataoka, J T Woo, A Yamada, T Yoshida, T Nishimura, N Otake, K Nagai
PMID9331989
ABSTRACT
Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans: the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8+ CTL clone at IC50 values of 30 microM and 50 microM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.
MATERIALS