- Expedient Route to the functionalized calyciphylline A-type skeleton via a Michael addition-RCM strategy.
Expedient Route to the functionalized calyciphylline A-type skeleton via a Michael addition-RCM strategy.
Organic letters (2011-09-09)
Filippo Sladojevich, Iacovos N Michaelides, Darses Benjamin, John W Ward, Darren J Dixon
PMID21899283
ABSTRACT
An efficient, robust, and scalable strategy to access the functionalized core of calyciphylline A-type alkaloids has been developed starting from commercially available 3-methylanisole. Key features of this approach are an intramolecular Michael addition/allylation sequence and a ring-closing metathesis step.
MATERIALS