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  • [Maintaining opioid abstinence long after inpatient treatment with opioid substitution in an addictology hospital unit].

[Maintaining opioid abstinence long after inpatient treatment with opioid substitution in an addictology hospital unit].

Revue medicale de Bruxelles (2013-08-21)
O Bouab, P Lahmek, N Meunier, H-J Aubin, L Michel
ABSTRACT

Assess the effectiveness of hospital detoxification of opiate substitution treatment (OST) in patients who failed to withdraw as outpatients. Retrospective study, conducted among patients admitted for withdrawal of OST in an addiction unit between 2005 and 2011. Referent physicians were interviewed about outcomes at M2, M3, M6 and M12. 47 patients were hospitalized for OST withdrawal. The opioid abstinence rates at 2, 6 and 12 months were 60, 28 and 21 %. No death occurred within 12 months after withdrawal. The only variables significantly associated with the M3 opioids abstinence were : age at admission and among the patients admitted for buprenorphine withdrawal, a low dose of buprenorphine at admission. OST withdrawal in a specialized inpatient unit among patients with failure of outpatient withdrawal appears as an option, with an efficacy at least comparable to other methods of detoxification. It allows a comprehensive care and to prevent the risk of overdose.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Buprenorphine hydrochloride
Supelco
Buprenorphine hydrochloride solution, analytical standard, for drug analysis
Supelco
Buprenorphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Supelco
Buprenorphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®