- Diastereoselective synthesis of allosecurinine and viroallosecurinine from menisdaurilide.
Diastereoselective synthesis of allosecurinine and viroallosecurinine from menisdaurilide.
The Journal of organic chemistry (2008-09-11)
Gisela G Bardají, Mariona Cantó, Ramón Alibés, Pau Bayón, Félix Busqué, Pedro de March, Marta Figueredo, Josep Font
PMID18781804
ABSTRACT
A new and versatile synthetic route to Securinega alkaloids is reported. The first synthesis of allosecurinine has been accomplished in seven steps and 40% yield, starting from (+)-menisdaurilide, using a vinylogous Mannich reaction as the key transformation. Similarly, viroallosecurinine has been synthesized from (-)-menisdaurilide.
MATERIALS