- Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages.
Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages.
Antimicrobial agents and chemotherapy (2004-05-25)
Gary D Ewart, Najla Nasr, Hassan Naif, Graeme B Cox, Anthony L Cunningham, Peter W Gage
PMID15155246
ABSTRACT
We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.
MATERIALS