- A direct synthesis of pyrrolocytosine from 5-iodocytosine.
A direct synthesis of pyrrolocytosine from 5-iodocytosine.
Nucleosides, nucleotides & nucleic acids (2005-10-27)
R H E Hudson, A K Dambenieks, R D Viirre
PMID16247992
ABSTRACT
We have employed a tandem Sonogashira/annulation reaction between 5-iodocytosine derivatives and terminal alkynes to yield the fluorescent bicyclic nucleobase pyrrolcytosine. Pyrrolocytosine bearing substituents only on the pyrrole ring are conveniently synthesized from 5-iodocytosine. Water soluble pyrrolocytosines are being investigated as reporter groups in SNP analysis.
MATERIALS