Highly potent and selective ligands for histamine H3-receptors.

Highly potent and selective ligands for histamine H3-receptors.

Nature (1987-05-14)

J M Arrang, M Garbarg, J C Lancelot, J M Lecomte, H Pollard, M Robba, W Schunack, J C Schwartz

ABSTRACT

New drugs selective for histamine H3-receptors can be used to establish that these receptors are involved in the feedback control of histamine synthesis and release, and to demonstrate their distribution in the brain and peripheral tissues. These drugs provide new tools for affecting physiological and possibly pathological conditions in which histamine is involved.

MATERIALS

Product Number

Brand

Product Description

T123

Sigma-Aldrich

Thioperamide maleate salt, solid

H128

Sigma-Aldrich

(R)(−)-α-Methylhistamine dihydrochloride, solid, ≥98% (HPLC)