- Facile synthesis of substituted 5-amino- and 3-amino-1,2,4-thiadiazoles from a common precursor.
Facile synthesis of substituted 5-amino- and 3-amino-1,2,4-thiadiazoles from a common precursor.
Organic letters (2009-12-17)
Paul M Wehn, Paul E Harrington, John E Eksterowicz
PMID20000443
ABSTRACT
A novel approach to the synthesis of substituted 5-amino- and 3-amino-1,2,4-thiadiazoles beginning from a common precursor has been achieved. Derivatization by palladium-catalyzed Suzuki-Miyaura coupling enables the rapid preparation of analogs around this pharmaceutically relevant core. FMO calculations rationalize the observed chemoselectivity for coupling at chlorine.
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