Skip to Content
MilliporeSigma
HomeProductsPharma & Biopharma ManufacturingChromatographyReverse Phase/Normal Phase Chromatography Resins

Reverse Phase/Normal Phase Chromatography Resins

Two bottles of PharmPrep® silica sorbent used in purification of peptides and small proteins, one smaller for laboratory-scale applications and one larger for industrial-scale use, both with blue labels detailing their suitability for various separation requirements in manufacturing processes.

Our silica gel chromatography sorbents and gels offer a wide range of choices depending on your separation requirements: whether you need excellent reproducibility and optimal resolution, or a more economic and versatile material, our normal-phase and reverse-phase products include silica gel products for all manufacturing scales.

Related Resources

  • Guide: Biochromatography Portfolio Guide

    Bulk Resin, Membranes and Prepacked Columns

  • Guide: Chromatography Product Selection Guide
  • Datasheet: PharmPrep® P Sorbent

    PharmPrep™ P Sorbent is a new silica sorbent with spherical particles available in two sizes: 10 and 20 µm. It is designed for the polishing step of peptides, biopharmaceuticals, and pharmaceutical APIs. Produced by spray drying, it ensures consistent batch-to-batch purification and regulatory compliance.

  • Datasheet: LiChroprep® Sorbent

    Preparative chromatography efficiently purifies valuable compounds, delivering high purity levels rapidly and economically. Our surface-modified silica sorbents, like LiChroprep®, are designed to meet specific manufacturing needs and offer good separation performance and stability at a reasonable cost.

Related Webinars

Slide 1 of 3
An open laptop with a colorful display featuring a stylized human figure in blue on the right and a pink rectangle on the left against a yellow background.

Webinar: How Continuous Chromatography Increases Productivity

Increase your productivity 4-20x through applying the principle of continuous chromatography.

An open laptop with a colorful display featuring a stylized human figure in blue on the right and a pink rectangle on the left against a yellow background.

Webinar: Overall Process Development for Insulin Purification - from Capturing to Filtration

How to complete a combined & optimized method for complete downstream processing of recombinant human insulin & select the most suitable phase combinations.

An open laptop with a colorful display featuring a stylized human figure in blue on the right and a pink rectangle on the left against a yellow background.

Webinar: Combined pH/Salt Gradients for the Separation of Challenging Protein Variants

How to apply the theory of Linear Gradient Elution, define the best separation conditions with dual gradients, and transfer to a large-scale process.

Reversed phase chromatography sorbents

PharmPrep® P RP sorbent is used for efficient polishing of small peptides like insulin and other APIs, including antibiotics and hormones. These sorbents are also available in prepacked stainless-steel columns.
LiChroprep® RP sorbents provide fast, effective, reproducible separation of peptide purification processes.

Normal-phase chromatography sorbents

Our PharmPrep® P Si and LiChroprep® Si products are well-suited for cost-effective, reliable polishing of biopharmaceutical and pharmaceutical APIs.

Standardized silica gels

Our standardized silica gels are widely used to purify high-value compounds in ton quantities. These silica gels are produced for adsorption and chromatography processes and are available in multiple particle sizes, and pack sizes from 500 g to 400 kg.

Silica Gel 60 is an irregularly shaped silica gel matrix ideal for simple adsorption processes and normal-phase chromatography.

Multifunctional sorbents

Aluminum oxide, available with pore diameters of 6 mm, 9 mm, and 15 mm, is a versatile sorbent for preparative chromatography. Aluminum oxide exhibits higher pH-stability than silica gel, especially in the alkaline range.

Standardized Aluminum Oxide 90 is a sorbent of medium polarity and is frequently used when the cation exchange properties of basic alumina are required. It may be used as an alternative to activated carbon.

Florisil® silicate is a polar, highly selective magnesium silicate gel, well-suited for separation of steroids, alkaloids, and antibiotics.

Related Product Categories
Chromatography Columns for Bioprocessing
Chromatography columns are critical to the successful separation of your valuable molecules. We provide columns from lab scale to pilot and process scale. From screening to large-scale production, our columns provide robust and consistent performance with the processing flexibility you need.
Chromatography Systems for Bioprocessing
Single-use and multi-use chromatography systems are critical for the separation of your valuable molecules. We provide standard and custom systems from pilot to process-scale, offering robust and consistent performance with the processing flexibility you need.
Ion Exchange Chromatography Resins
Ion exchange (IEX) chromatography separates biomolecules based on the difference in charge between the target molecule and chromatography resin.
Size Exclusion Chromatography Resins
Size exclusion chromatography (SEC) is a purification method used for separating substances based on their molecular size. Widely used in commercial bioseparation processes, size exclusion chromatography is a versatile technique because buffer composition does not impact separation effectiveness.
Affinity Chromatography Resins
Affinity chromatography is often used during the capture phase to isolate the target molecule and reduce process volume. Our range of affinity resins includes Protein A, anti-A and anti-B, and metal chelate resin, designed for high throughput and cost-effective purification.
Buffers & pH Adjusters
Our broad portfolio of buffer materials manufactured according to GMP guidelines includes excipients specifically for drug formulation and manufacturing, including high-risk applications. Whether your product is a small or large molecule drug, we offer high-quality buffers and pH adjusters with regulatory support.
RELATED APPLICATIONS
Pharma & Biopharma Startup Hub
Your new molecule or therapy begins its journey here. Find solutions and resources to navigate your path to successful drug discovery, development, and commercialization.
RELATED SERVICES
Emprove® Chromatography
The Emprove® Chromatography portfolio streamlines resin selection and qualification for biopharmaceutical manufacturers, built to address process-specific needs at steps from early to late downstream.
Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?