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Supelco

2,6-Dimethylaniline

analytical standard

Synonym(s):

2,6-Xylidine, 2-Amino-1,3-dimethylbenzene, 2-Amino-m-xylene

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About This Item

Linear Formula:
(CH3)2C6H3NH2
CAS Number:
Molecular Weight:
121.18
Beilstein/REAXYS Number:
636332
EC Number:
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:

grade

analytical standard

Quality Level

vapor pressure

<0.01 mmHg ( 20 °C)

assay

>99% (GC)

CofA

current certificate can be downloaded

packaging

ampule of 1000 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.560 (lit.)

bp

214 °C/739 mmHg (lit.)

mp

10-12 °C (lit.)

density

0.984 g/mL at 25 °C (lit.)

application(s)

environmental

format

neat

storage temp.

2-30°C

SMILES string

Cc1cccc(C)c1N

InChI

1S/C8H11N/c1-6-4-3-5-7(2)8(6)9/h3-5H,9H2,1-2H3

InChI key

UFFBMTHBGFGIHF-UHFFFAOYSA-N

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General description

2,6-Dimethylaniline is a alpha2-adrenergic agonist metabolite of xylazine, which can find applications as a sedative agent in food producing animals. It is also used in industries as a synthetic intermediate in the production of several products like dyes, pesticides and synthetic resins.

Application

2,6-Dimethylaniline may be used as an analytical standard for the determination of the analyte in animal samples, human biological samples, milk samples and pharmaceutical preparations by chromatography and electroanalytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

195.8 °F - closed cup

flash_point_c

91 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Simultaneous determination of xylazine and its major metabolite, 2, 6-dimethylaniline, in bovine and swine kidney by liquid chromatography
Holland DC, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 76(4), 720-724 (1993)
Tumor-promoting activity of 2, 6-dimethylaniline in a two-stage nasal carcinogenesis model in N-bis (2-hydroxypropyl) nitrosamine-treated rats
Koujitani T, et al.
Cancer Letters, 142, 161-171 (1999)
Synthesis, Characterization, and Comparative 32P-Postlabeling Efficiencies of 2, 6-Dimethylaniline? DNA Adducts
Goncalves.LL, et al.
Chemical Research in Toxicology, 14, 165-174 (2001)
Determination and temperature effects of lidocaine (Lignocaine) hydrochloride, epinephrine, methylparaben, 2, 6-dimethylaniline, and p-hydroxybenzoic acid in USP Lidocaine Injection by ion-pair reversed-phase high pressure liquid chromatography
Smith DJ
Journal of Chromatographic Science, 19(5), 253-258 (1981)
Emil Baczyński et al.
Acta poloniae pharmaceutica, 59(5), 333-339 (2003-02-27)
2,6-Dimethylaniline (2,6-DMA) and o-toluidine (o-TLD) together with their decomposition products are potential technological impurities of Pharmaceuticals used for local anaesthesia, in which lidocaine and prilocaine appear as active substances. Pharmacopoeial analytical methods for the determination of these impurities are little

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